I for one personally prefer the Enterprise-D first and foremost. It was armed with virtually every Starfleet function, from exploration to science to diplomacy to defense, as the Federation's flagship basically should. Plus, the design was the sleekest, the crew aboard had the greatest chemistry, they tackled the greatest motifs and themes worth exploring during their mission, and of course, it was commanded by none other than Captain Jean-Luc Picard, the finest and most definitive example of a Starfleet officer.
Otherwise, I just love this lovely rendition of the ship that we saw in "Remembrance", the pilot of Star Trek: Picard two years ago. As for yourselves, just feel free to let me know in the comments section below.