- John F. Kennedy begins his term as the 35th President of the United States. (TOS: "The Cage") He later gives his famous "Decision to Go to the Moon" speech. (TOS-R: "The Cage")
- Twenty-five years later, the magazine OMNI released a "Special Souvenir Edition" of celebrating the anniversary of "American Manned Spaceflight". (Star Trek IV: The Voyage Home)
- In 2372, Jake Sisko received a holosuite program from Nog featuring this season's New York Yankees baseball team against the 1978 Boston Red Sox. The outcome of the game was Yankees 7, Red Sox 3. (DS9: "For the Cause")
- In 2375, Nog assumed the role of Vic Fontaine's accountant and went over the receipts of 1961. (DS9: "It's Only a Paper Moon")
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