- Humanity unofficially makes first contact with the Klingon Empire when Klaang crash-lands in Broken Bow, Oklahoma. (ENT: "Broken Bow")
- Earth Starfleet launches Enterprise NX-01, its first starship to use the warp five engine, opening up a new age of exploration for Earth. Enterprise also begins Humanity's involvement in the Temporal Cold War with the first encounter with the Cabal. (ENT: "Broken Bow")
- Enterprise NX-01 makes contact with Sluggo, whom they relocate to another planet after it has difficulty adjusting to the environment on the ship.
- Enterprise NX-01 ran along a protostar a week before the incident at P'Jem. (ENT: "The Andorian Incident")
- 19th – Humanity makes first contact with the Andorians; the Andorian Imperial Guard finally corroborates the existence of a Vulcan surveillance listening post at P'Jem. (ENT: "The Andorian Incident")
- The Andorians destroy the facility on P'Jem, though they give sufficient warning for personnel present to evacuate first. (ENT: "Shadows of P'Jem")
- The Paraagan colony on Paraagan II was visited by outsiders. The foreman of the colony would later inform T'Pol of this fact during the Enterprise NX-01's visit to the planet six months later. (ENT: "Shockwave")
- Other Earth first contacts this year include the Akaalis, the Axanar, the Coridanites, the Eska, the Kantare, the Malurians, the Menk, the Valakians, and the Xyrillians. (ENT: "Fight or Flight", "Unexpected", "Civilization", "Dear Doctor", "Shadows of P'Jem", "Rogue Planet", "Oasis")
- Earth reestablishes contact with the lost Terra Nova colony. (ENT: "Terra Nova")
- T'Pol confides in Commander Charles Tucker III that she had been arranged to be married, a situation that was causing her some concern. (ENT: "Breaking the Ice")
- Archer's Comet is discovered by the crew of the Enterprise NX-01 and named after the ship's captain, Jonathan Archer. (ENT: "Breaking the Ice")
- Hernandez begins to move away from an explorer's mindset. (ENT: "Home")
- Trip Tucker experiences what is believed to be the first inter-species pregnancy involving a Human. (ENT: "Unexpected")
- Travis Mayweather and Gannet meet each for the last time before the Coalition of Planets talks on Earth in 2155. (ENT: "Demons")
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