- The United Federation of Planets is officially formed (treaties signed and ratified) in San Francisco by representatives from Earth, Vulcan, Andoria, and Tellar. (TNG: "The Outcast"; ENT: "Zero Hour", "These Are the Voyages..."; VOY: "Homestead")
- Starfleet Academy is established. (TNG: "The First Duty"; DS9: "Paradise Lost")
- The MACOs are disbanded and MACO personnel are absorbed into the ranks of Starfleet and possible other agencies in United Federation of planets. They are given ranks in Starfleet equal to their former MACO rank. One of these officers is Major Balthazar Edison, who is given the rank of captain and command of the USS Franklin. (Star Trek Beyond)
- Charles Tucker III dies. (ENT: "These Are the Voyages...")
- Enterprise NX-01 is retired from service. (ENT: "These Are the Voyages...")
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