- Leonard McCoy heads a mass-inoculation program on the Draman planet Dramia II. After his force leaves, a massive plague strikes the planet, killing most of its people. The Dramans hold him responsible and nineteen years later he is arrested, with Federation approval, and put on trial for the outbreak. (TAS: "Albatross")
- Leland conducts a mission to Deneva that unfortunately involves the wrong ambassador. (DIS: "Saints of Imperfection")
- According to the Star Trek Chronology, Christopher Pike begins his first five-year mission aboard the USS Enterprise this year.