- Captain Kirk encounters Sybok, Spock's brother. Sybok makes the Enterprise travel through the Great Barrier in search of the planet Sha-Ka-Ree and God. They find Sha-Ka-Ree and a very powerful life form, but the life form is not God (Star Trek V: The Final Frontier).
- This is the last time till Evolution that there was a ship wide systems malfunction, not including Contagion.
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