- Boradis III is the first planet in the Boradis system colonized by the Federation. Over the next thirty-four years, three other settlements will appear in this star system. (TNG: "The Emissary")
- June - Joseph Sisko meets a woman named Sarah in Jackson Square. (DS9: "Image in the Sand")
- August - Joseph and Sarah get married, following a two-month courtship. (DS9: "Image in the Sand")
- The final script for DS9: "Destiny" suggests Vedek Yarka was born sometime between 2321 and this year. 
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