- Lewis Zimmerman is assigned to the Holo-Programming Center on the station. He begins developing what he refers to as a "Holo-Doc": a holographic doctor intended to assist in medical emergencies. (VOY: "Projections")
- The Potemkin attempts to contact the failed Federation colony on Turkana IV. They are warned that anyone beaming down to the planet will be killed. (TNG: "Legacy")
- The Potemkin sends down an away team, led by Lieutenant William T. Riker to evacuate a research station on Nervala IV. Due to atmospheric distortion, the Potemkin transporter chief attempts to use two confinement beams to transport Lieutenant Riker, the last one on the planet. Although the first confinement beam works and a Riker is beamed aboard, the second beam is unknowingly reflected back to the planet, creating another William T. Riker. The second Riker would later be discovered by the crew of the USS Enterprise in 2369. (TNG: "Second Chances")
- Lieutenant William T. Riker is promoted to lieutenant commander for "exceptional valor during the evacuation of the research station on Nervala IV." (TNG: "Second Chances")
- Dr. Dalen Quaice is assigned to the starbase. He moves there with his significant other, Patricia. (TNG: "Remember Me")
- Roana and her husband, both Bajoran entrepreneurs, open a store on the Promenade of Terok Nor, after closing down their shop on Bajor after seventeen years. (DS9: "Rivals")
- Botanists Kevin and Rishon Uxbridge move from New Martim Vaz on Earth to the Federation colony on Rana IV. (TNG: "The Survivors")
- The father of Jeremy Aster dies from a Rushton infection. (TNG: "The Bonding")
- Vash is hired as the personal assistant to Dr. Samuel Estragon, a scientist devoted to finding the legendary Tox Uthat. (TNG: "Captain's Holiday")
- An issue of the Journal of Starfleet Technology is released in August of this year. (TNG: "Redemption II")
- Obsidian Order operative Iliana Ghemor volunteers for an undercover assignment on Bajor. She is surgically altered to appear as a Bajoran and infiltrate the Resistance. Her memories are erased. (DS9: "Second Skin")
- The Shakaar resistance cell, including a young Kira Nerys, spends the entire winter hiding in the Dahkur Hills from Cardassian sensor sweeps. (DS9: "Second Skin")
- Rom leaves Ferenginar. (DS9: "Family Business")
- Lidell marries Tolen Ren on Banea. (VOY: "Ex Post Facto")
- William T. Riker and Deanna Troi meet for the first time on Betazed while Riker is stationed there as a lieutenant. (TNG: "Encounter at Farpoint")
- Seven of Nine emerges from a Borg maturation chamber, having been assimilated five years before. (VOY: "Collective")
- One of the children living on Deep Space 9 in 2369 was born in this year. (DS9: "A Man Alone")
- According to the Star Trek Chronology, this year comprises the stardate range of 38000 to 38999.
- In material created for Star Trek Generations, Jean-Luc Picard received the Grankite Order of Tactics on stardate 38946.2 for "development of the Picard Maneuver during the Battle of Maxia." This material was included in the Picard family album, but was not seen on-screen.
- According to the Star Trek Chronology, this is the year Worf graduated from Starfleet Academy.
- According to the script for "Disaster", Jay Gordon Graas was seven years old, placing his birth in this year.
- According to the script for "Imaginary Friend", Clara Sutter was seven years old, placing her birth in this year.
- According to the non-canon video game Star Trek: Starship Creator, B.G. Robinson averted a serious transporter accident during a midshipman cruise on the USS Cornwall during her time at Starfleet Academy in this year.