- Communications between Voyager and the Alpha Quadrant improve when real-time communication is made possible. (VOY: "Author, Author")
- Lieutenant Joe Carey is killed while on an away mission to retrieve the Friendship 1 probe, which had contaminated the planet Uxal in the Delta Quadrant. (VOY: "Friendship One")
- Neelix departs the USS Voyager to live with a group of Talaxians living in an asteroid field; he becomes the permanent Federation ambassador in the Delta Quadrant. (VOY: "Homestead")
- Lieutenant Ayala transfers from the operations division to the command division aboard the USS Voyager. (VOY: "Renaissance Man")
- Captain Kathryn Janeway is captured by the Hierarchy; Voyager's EMH has to masquerade as the captain in order to save her and protect the crew. (VOY: "Renaissance Man")
- One of the six Borg transwarp hubs is found by the crew of Voyager; Captain Kathryn Janeway at first orders the ship to avoid it at all costs. (VOY: "Endgame")
- Voyager concludes its seven-year odyssey through the Delta Quadrant by using the Borg transwarp network to return to the Alpha Quadrant; the ship is aided by technology brought from the future by Kathryn Janeway from the year 2404. (VOY: "Endgame")
- Miral Paris, daughter of B'Elanna Torres and Tom Paris, is born during Voyager's trip home. (VOY: "Endgame")
- Following the return of Voyager to Earth, Kathryn Janeway is promoted to Admiral. (Star Trek Nemesis)
- Given that VOY: "Endgame" takes place sometime after VOY: "Homestead" (which in turn takes place on the 315th anniversary of first contact), and taking Seven of Nine's statement in the former episode that the events of VOY: "Human Error" take place three months previously, we can conclude that Human Error - Endgame take place in this year.
- Janeway's promotion is speculation based on her rank in Nemesis, which took place in mid-2379.
- The non-canon events of Star Trek: Voyager set after the series begin in this year.
- The simulation Star Trek: Bridge Commander and part of the FPS Star Trek: Elite Force II was set in this year.