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An antimatter warhead was a type of antimatter weapon warhead that contained an antimatter explosive.

Photonic torpedoes were armed with variable yield antimatter warheads. The fact that the Earth Starfleet vessel Enterprise NX-01 was using weapons with antimatter warheads in 2153 came as a surprise to the Klingons. (ENT: "The Expanse")

In 2268, the crew of the USS Enterprise utilized a telemetry probe armed with an antimatter warhead to destroy the space amoeba. The warhead was a simple magnetic bottle containing the charge, programmed with a timing detonator fuse. (TOS: "The Immunity Syndrome")

In 2373, the Maquis were known to have access to such weapons as antimatter warheads, tricobalt explosives and biogenic weapons. (DS9: "Blaze of Glory")

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