An auto-destruct sequencer was a device aboard Romulan starships used to engage auto-destruct.

In 2366, Admiral Alidar Jarok's Romulan scout ship was equipped with an auto-destruct sequencer and when he left his ship to beam aboard the USS Enterprise-D, he set the sequencer to make sure that the technology wouldn't fall into Federation hands. (TNG: "The Defector")

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