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Beta-endorphin was an opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system.

In 2375, The Doctor found that Harry Kim's beta-endorphins were abnormally elevated following sex with Derran Tal, and in consequence had no doubt Kim felt wonderful. (VOY: "The Disease")

In 2377, The Doctor listed increased beta-endorphin production among the physiological responses that were present when one person had romantic feelings for another. This information was supplied to Icheb, who was laboring under a misapprehension involving B'Elanna Torres. (VOY: "Nightingale")

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