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A biological weapon was a weapon that operates by spreading a pathogen such as a virus or a bacterium to the intended targets. This weapon is generally either lethal or at least physiologically devastating to those afflicted.

Malcolm Reed told General Gosis a lie during the interrogation when he said he and Captain Jonathan Archer were genetically enhanced and their immune systems were resistent to chemical and biological weapons. (ENT: "The Communicator")

On Earth, the use of biological weapons was outlawed by the Geneva Protocol of 1928 and 2155. (DIS: "Context Is for Kings")

The Tarellian civilization was wiped out by biological weapons during a civil war, leaving a small number of plague-carrying survivors who escaped, typically infecting the populations of other planets after establishing contact. (TNG: "Haven")

The Dominion at times used biological weapons to make examples of populations that resisted their rule, including the Teplans, afflicted with the blight, and the inhabitants of Boranis III. (DS9: "The Quickening", "Inter Arma Enim Silent Leges")

In 2375, Species 8472 accused the USS Voyager to have created biological weapons and infect their species. In addition they accused Voyager to ally with the Borg. (VOY: "In the Flesh")

The Brunali created a spaceborne virus that they then used to infect the Borg via children they deliberately allowed to be assimilated. Icheb was one such child, who (unknowingly) successfully transferred the virus to the Borg cube that assimilated him, killing all of the crew except for those Borg drones still in their maturation chambers. (VOY: "Collective", "Child's Play")

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