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Bipolar personality disorder was a medical condition characterized by extremes of emotion.

Following Lon Suder's murder of Frank Darwin in 2372, Kes found no tendency towards bipolar disorder in Suder's neurogenetic markers. (VOY: "Meld")

In 1996, The Doctor told Henry Starling that his belief that the USS Voyager crew was attempting to steal "his" timeship, because they thought he'd be an easy target, was a paranoid response indicative of bipolar personality disorder. (VOY: "Future's End, Part II")

The novelization of First Contact suggested that Zefram Cochrane suffered from bipolar disorder, a condition which was initially treated with a cerebral implant but which he was unable to refill in the aftermath of World War III, leading him to self-medicate with alcohol.

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