Boston was mentioned in the song "Let's Get Away from It All" from 1941. This song was featured in the Dixon Hill holo-novels. (TNG: "Manhunt") In other excerpts from the Dixon Hill series, one character Doctor John Rawley, had left Fairbridge, Berkshire County, to attend a state medical convention in Boston. After the convention ended, the doctor returned to Fairbridge. (TNG: "The Big Goodbye")
In 2376, Commander Pete Harkins' wife Angie had a sister named Hope who lived in Boston. That year, she was visiting San Francisco and Harkins suggested to coworker Lieutenant Reginald Barclay that he may like to meet her; they later started dating. (VOY: "Pathfinder")
In "The Neutral Zone", the name of this city was never mentioned in dialog; the name came from the remastered Clare Raymond family tree. Charles W. Raymond was named after Charles Winchester, a character from the dramedy M*A*S*H. This character was from Boston.