The Cancri system was an inhabited neutral planetary system which was located somewhere in the Alpha or Beta Quadrant.
In 2256, Cancri IV hosted peace negotiations between the Klingons and the Federation. (DIS: "Lethe")
In the Bayer designation system, "Cancri" is used in the names of stars in the constellation Cancer.
The revised edition of the Stellar Cartography: The Starfleet Reference Library ("History of the United Federation of Planets") located the Cancri system in the Beta Quadrant. Furthermore, the reference work identified the system as 81 Cancri.