The Cardassian Science Ministry was a government department of the Cardassian Union responsible for scientific research and exploration on behalf of the Cardassians. The department fell under the Cardassian military instead of the civilian government.

The Ministry was given several maxims from the military, one of which was to not to make any project appear too dangerous. This could result in reporting on computer simulations to only include likely outcomes instead of all possible ones.

The Ministry was largely female-dominated in the mid-24th century as most males joined military branches which were more combat-oriented. This also led to a stereotype that males did not have the capability of pursuing science.

In 2371, the Ministry was tasked with helping a joint team develop communications through the Bajoran wormhole. The team included Ulani Belor and Gilora Rejal. (DS9: "Destiny")

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