The chameleon was a small lizard native to Earth.

While discussing the M-113 creature's natural ability to take other forms, Robert Crater and Leonard McCoy discussed the similarity the creature bore to the chameleon, which possessed a natural ability to use protective coloring to survive in nature. (TOS: "The Man Trap")

Doctor Beverly Crusher compared the Tarchannen III species to a chameleon, as the skin of the lifeform had similar mimetic qualities. (TNG: "Identity Crisis")

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