Eventually, Vance married his wife and the two had a daughter. Vance's wife and daughter lived at Federation Headquarters for a time before Vance realized that it was too dangerous for them to live there. Vance stayed on the station, while his wife and daughter left for parts unknown. (DIS: "That Hope Is You, Part 2")
Shortly thereafter, he met with Captains Bandra, L'Teis Kardashev, Rahma and Saru and handled out assignments. He tasked Bandra and the USS Le Guin with the two month supply run to Na'Seth, Kardashev with supplying shields to Reilling VII as they were dealing with solar flares, and Rahma with resupplying Kaijur XII with Replicator replacement technology as they were experiencing a food shortage.
When presented with Burnham and Sylvia Tilly's new findings about the Burn, he informed Burnham and Saru that the data they required to verify their findings could only be obtained from Ni'Var, the planet formerly known as Vulcan. He also informed them that Ni'Var was now home to both the Vulcans and Romulans, but had seceded from the United Federation of Planets as they believed the Federation had pushed them into developing dilithium replacement technology which had ultimately been the cause of the Burn itself. Vance decided to send Burnham as the Federation's representative to Ni'Var due to her relationship with her late brother, Ambassador Spock. He saw her as the only person who could re-open negotiations with Ni'Var. Vance sent a message to Ni'Var telling them of Discovery's spore drive, its jump to the future and Spock's sister. (DIS: "Unification III")
Following Discovery's mission to Ni'Var, Vance agreed to allow Discovery to take Booker back to his homeworld of Kwejian and for its crew to act as observers. When a cure for Commander Georgiou's condition was found on Dannus V, Vance allowed Discovery to take her there to help. Following Georgiou's departure, Vance spoke with Saru about allowing Booker to use Emerald Chain technology aboard Discovery and cautioned him about Osyraa's desperation for dilithium. He also saw that Saru was distracted by the KSF Khi'eth's Kelpien crew. Vance was then informed by Saru and Burnham about Theta Zeta as a planet made of dilithium and being ground zero for the burn. He asked if the survivor of the Khi'eth could have been involved. Saru did not believe so. Vance also said that several Chain ships were conducting military exercises near Kaminar and that he had to send part of the fleet to Saru's homeworld. Vance said that the fleet would protect Kaminar, and ordered Saru to find the survivor. (DIS: "The Sanctuary", "Terra Firma, Part 1", "Terra Firma, Part 2", "Su'Kal")
Vance was forced into negotiations when Minister Osyraa hijacked the Discovery and got through Federation Headquarters' distortion field. Vance was given permission by the Federation President to conduct the negotiations with Osyraa. Vance was surprised when Osyraa offered an armistice between the Federation and the Chain that would bring peace between their organizations. However, Vance rejected the armistice due to the fact that the Emerald Chain's representative would merely be a puppet for Osyraa and she would not stand trial for her actions. Upon Osyraa's return to Discovery, Vance ordered the USS Voyager-J and the fleet to open fire on Discovery to prevent Osyraa from escaping. Vance also ordered Paul Stamets, despite his objections, to the Foresight to prevent Osyraa from using Discovery's spore drive. (DIS: "There Is A Tide...")
Vance was then informed that Ni'Var had sent a fleet to assist. He was then contacted by Osyraa and Burnham, who asked Vance to let them go. Vance was hesitant at first but went along with Burnham's request. He then sent the Federation and Ni'Var fleet to pursue Discovery to Base 755. Following the destruction of the Viridian, Vance met with Aditya Sahil and gave him a commission as a lieutenant. He also promoted Burnham, on his and Saru's recommendation, to Captain. (DIS: "That Hope Is You, Part 2")
In 3190, Vance was reunited with his wife and daughter for the unveiling of Archer Spacedock. He gave them a tour. Vance then sent Discovery to render aid in response to Deep Space Repair Beta Six's distress call. He also allowed President Laira Rillak to accompany Discovery's crew on the mission. Vance then authorized a joint mission between the Qowat Milat under Dr. Gabrielle Burnham and an away team under Captain Burnham to apprehend rogue Qowat Milat sister J'Vini for the murder of USS Credence's XO, Commander Patrick Fickett. Upon J'Vini's surrender to Captain Burnham and Doctor Burnham, Vance supported Rillak's choice to extradite J'Vini back to Ni'Var. (DIS: "Kobayashi Maru", "Choose to Live")
When the DMA threatened United Earth and Titan and Ni'Var, Vance brought Federation Headquarters and all of the ships that he could muster to evacuate the planets while using Headquarters' shields to buy Earth more time. Vance eventually ordered the crew to abandon ship to the USS Mitchell and all of the ships to leave while Vance himself remained behind to give the ships as much time as he could. Vance was joined by Sylvia Tilly and the two shared a drink while they waited for the end, discussing their lives and regrets, particularly Vance's regret that he wasn't there for his daughter more. Tilly reassured Vance that his daughter loved him and the two watched in amazement as the DMA disappeared, Discovery's first contact mission having been successful.
"The safety and security of whatever's left of the Federation must take priority over everything else."
"I never listened to advice when I was green, but take it from an old salt who's made a lot of bad calls in his day. A crew member is drowning. If we let her, then your crew will never look at you, or the Federation the same way again. And you will never look at yourself the same way either."
"The past is the only light with which we can see the future."
Charles Vance was played by Oded Fehr.