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A DNA probe was a piece of technology used in medical tests.

In 2373, The Doctor prepared a DNA probe to test Ensign Parsons's glial cells, which lead to the conclusion that he had a microbial infection. When he tried to tell his holographic wife Charlene about it, she brushed him off, saying she was late for her speaking engagement at the Bolian embassy. (VOY: "Real Life")

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