Defiant could refer to:
- Defiant history, the history of such vessels
- HMS Defiant, The British Royal Navy ship
- ISS Defiant, a Terran Rebellion starship from the 24th century mirror universe
- USS Defiant (2370), registry NX-74205, lead ship of the class, the first Defiant-class starship to bear the name
- USS Defiant (2375), the second Defiant-class starship to bear the name (formerly the USS Sao Paulo)
- USS Defiant (NCC-1764), a Constitution-class starship
- Defiant-class escort, a Federation starship type
- Real world
- "Defiant", a Season Three episode of Star Trek: Deep Space Nine
- USS Defiant (alternate reality), an alternate universe ship mentioned only in the script of Star Trek.
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