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The Denobulan Science Academy was a university on Denobula. Its staff was responsible for coordinating Denobulan scientists.

In 2152, geologists Yolen, Trevix, and Zepht went to Xantoras to study the unique speleothems there.

In February of 2153, the Xantoras government was overthrown by a xenophobic faction. The new government instituted a deadline for all aliens to be off the planet or they'd be imprisoned, and possibly executed. The Denobulan Science Academy sent a message to Dr. Phlox, to ask Captain Archer to retrieve them, as Enterprise NX-01 was several days closer than the nearest Denobulan starship. (ENT: "The Breach")