Drexler could refer to:
- People
- D. Drexler, a 22nd century member of Earth Starfleet
- Doug Drexler (comedian), a comedian
- Douglas Drexler (civilian), a 24th century individual
- Douglas Drexler (Starfleet), a Starfleet officer in the 2360s and 2370s
- Places
- Drexler outpost, an outpost located in the Omega sector
- Drexler sector
- Production staff
- Doug Drexler, a production artist
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