Prior to 2151, the North Star became well-known, at least among the boomer community, for its involvement in a disaster. Matthew Ryan and his parents served aboard the ECS North Star; they were killed in the event, and Ryan was one of the few survivors. Subsequently, Ryan transferred to the ECS Fortunate. (ENT: "Fortunate Son")
This freighter was only mentioned in dialogue.
In the first draft script of "Fortunate Son", this vessel had the name the "Gallant" and was established as the first posting of Keene. However, as in the final version of the episode, the craft was referred to as having also included Ryan's parents among its crew and having been disastrously "lost."
According to Star Trek: Star Charts (p. 45) and Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), the ECS North Star was lost in 2147.