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An edema or swelling was an abnormal accumulation of fluid beneath the skin.

In 2371, Walter Baxter suffered moderate edema to his arm while working out in the gymnasium aboard the USS Voyager. (VOY: "Eye of the Needle")

In 2375, Chakotay received an edema beneath the anterior fossa of his cranium during a boxing simulation on the holodeck. (VOY: "The Fight")

In 2377, Iko suffered severe edema in his parietal lobe following a beating from Yediq that blocked vital neurotransmitters in his brain. The Doctor was able to bypass the edema with the help of some of Seven of Nine's nanoprobes. (VOY: "Repentance")

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