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Endeavour (OV-105) was a space shuttle orbiter that was operated by NASA for the United States of America on Earth during the 20th century.

In 2143, an assignment patch for the Endeavour mission STS-49 – crewed by Thomas Akers, David Brandenstein, Kevin P. Chilton, Richard Hieb, Bruce E. Melnick, Pierre J. Thuot, and Kathryn C. Thornton – was on display in the 602 Club. (ENT: "First Flight")

Enterprise guest star Terry Virts piloted the shuttle on a mission to the International Space Station in February 2010. Another former Endeavour astronaut, Mae Jemison, guest-starred in "Second Chances"

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