Enterprise or Enterprize could refer to:
- The series Star Trek: Enterprise (originally just called Enterprise)
- One of the various vessels named Enterprise (see Enterprise history for more):
- HMS Enterprize, the British galleon
- Enterprise (frigate), the frigate on which Jonathan Archer's drawing was based
- Enterprise OV-101, the Space Shuttle
- Any of the ships bearing the name USS Enterprise
- Any of the mirror universe ships bearing the name ISS Enterprise
- UEF Enterprise, a United Earth Fleet starship in an alternate timeline
- The notion of free enterprise
- The following novels:
- Pocket Books' tie-in series Star Trek: Enterprise
- Enterprise: The First Adventure
- My Brother's Keeper: Enterprise (novel)
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