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The Fermi was a Federation Type 6 shuttlecraft that was in service to Starfleet in the mid-24th century, attached to the USS Enterprise-D. It was shuttlecraft 16.

The Fermi was used to ferry relief supplies to the surface of Tagra IV during the Enterprise-D's mission there in 2369. (TNG: "True Q")

Captain Jean-Luc Picard, Ensign Ro Laren, botanist Keiko O'Brien, and Guinan took the Fermi to Marlonia. Upon their return, the Fermi was trapped in a molecular reversion field and destroyed. The crew beamed out, but were turned into twelve-year-olds after passing through the field. (TNG: "Rascals")

The Star Trek Encyclopedia (4th ed., vol. 1, p. 269) stated the Fermi was "named for Enrico Fermi, the 20th-century Italian-American physicist who developed the first nuclear fission reactor." The Encyclopedia identified the Fermi as shuttlecraft 09.