Florence was a city located in the Tuscany region of Italy on Earth, its inhabitants being called Florentines. It was home to Leonardo da Vinci during the 16th century. It was located along the Arno.

Within the holodeck of the USS Voyager, the holographic recreation of da Vinci wished to leave Florence and move to France, believing the people of Florence could not grasp his genius. (VOY: "Concerning Flight")

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