Forrester-Trent Syndrome was a rare degenerative neurological disorder. The disease caused tremor on hands and could also cause severe seizures. If untreated, the disease could result in paralysis or death.

Forrester-Trent was a genetic disease and was usually inherited from the parents. However, some cases had been reported in which the disease was caused by a random mutation.

The gene causing the disease appears to be dominant, as only one of the parents must carry it.

In 2370, neuro-stabilization regimen was the treatment used by Starfleet doctors. The treatment was not 100% reliable, but in most cases the patients responded to treatment well. In many cases the effects of the disease could even be reversed.

Jason Vigo suffered from Forrester-Trent Syndrome as a result of DNA re-sequencing. (TNG: "Bloodlines")

According to Star Trek: The Next Generation Companion, the syndrome derived its name from "The Battle" scriptwriter Larry Forrester and from the lead vocalist of the rock band Nine Inch Nails, Trent Reznor.(citation needededit)