(written from a Production point of view)
Primarily a stage actor, Kopyc is the best friend of DS9 co-star Armin Shimerman, who reportedly based his characterization of Quark on Kopyc. Besides DS9, the two of them also co-starred together in the 1998 film Looking for Lola (Kopyc played a waiter, Shimerman a maitre'd). Shimerman commented: "My best friend was one of the guest stars. His name is Frank Kopyc and he played the blue Bolian who's an assistant to Monte Markham's character. Frank is the man I modeled Quark after. He was my inspiration for Quark, so it was nice to have him right at my elbow. He's a fun-loving, sort of self- inquisitive type of guy who enjoys life, but at the same time always is worried about being first. And I don't mean that in a bad way. That's the way I like to play Quark. He's very human, and his problems are definitely serious ones and human ones. It's just that Quark sees the world from Frank's point of view." . (Star Trek: Deep Space Nine Companion (p. 393))
Kopyc commented: "I'm gay, number one, and I had a very difficult time adjusting in a very heterosexual community in upstate New York where it was all football and cowboys. Where I really found acceptance with my peers in high school was when I did a play. Where I really found acceptance with my peers in high school was when I did a play. I'd walk down the hall: "Oh, Frank, you were great in that play." And all of a sudden I became popular and made friends, and I'm thinking, "I'm good at this. I like this. I like the way this feels." (Los Angeles Magazine, March 2001)
Kopyc also had a small role in the 1990 science fiction blockbuster Total Recall. Co-starring in this film were fellow Star Trek actors Marc Alaimo, Roy Brocksmith, Robert Costanzo, Ronny Cox, Mel Johnson, Jr., Lycia Naff, Michael Champion, and the voice of Robert Picardo.
His other film credits include the 1991 action-thriller The Last Boy Scout (with Noble Willingham, Bruce McGill, and Frank Collison), the 1991 remake of Father of the Bride, 1996's Dunston Checks In (starring Jason Alexander and featuring Paula Malcomson), and 2000's Forever Lulu (with Michael J. Pollard).
Besides DS9, his other television work includes appearances on such programs as Parks and Recreation, Who's the Boss?, 3rd Rock from the Sun, and The West Wing.