A freeway was a type of highway used for motorized traffic, such as land vehicles, or vehicles that hovered a few feet over the road, such as hovercars.
A freeway was present at the Embarcadero of San Francisco in 1986. In the alternate reality, this freeway no longer existed as of 2260. (Star Trek VI: The Undiscovered Country; Star Trek Into Darkness)
In 2022, there was a media broadcast that an alternate James T. Kirk and La'an Noonien-Singh were watching somewhere near The Lakeview in Toronto. What they saw on the TV was footage of a freeway near Lakeshore East. (SNW: "Tomorrow and Tomorrow and Tomorrow")
In 2256, Lieutenant Paul Stamets likened the roots of the Prototaxites stellaviatori to an "intergalactic freeway system". (DIS: "Choose Your Pain")
In 2257 in Paris, when Michael Burnham learned from Sarek that the President of the United Federation of Planets was issuing her a pardon; the nearby freeway was flooded with traffic. (DIS: "Will You Take My Hand?")