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A gene pool was a group of genetic materials present in a species.

Some gene pools were considered insufficient for creating a society. In 2365, Wilson Granger explained that the Mariposans initial gene pool of two women and three men were too small a gene pool, necessitating that they turn to cloning to increase their population instead. (TNG: "Up The Long Ladder")

As of 2378, Q Junior was, among other chaotic behavior, tampering with primordial gene pools. (VOY: "Q2")

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