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Genetic degeneration or gene-sequence degradation was a disease that could affect clones grown with a certain process.

In 2369, the Ibudan clone was found to have this condition, having been murdered by Ibudan himself. (DS9: "A Man Alone")

In 2379, Shinzon, a clone of Jean-Luc Picard, suffered from this. (Star Trek Nemesis)

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