A genetic disorder was an error in a genome that was either hereditary or a result of mutations. Progeria was one example of a rare genetic disorder. (VOY: "Scientific Method")

Under Colonel Phillip Green's rule, those with genetic disorders were euthanized. In 2155, T'Pol noted that if John Frederick Paxton, the leader of Terra Prime, were alive during Green's rule, he himself would have been euthanized for having a genetic disorder, specifically Taggart's Syndrome. (ENT: "Terra Prime")

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