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A hazardous material was any material that could cause negative side effects for those coming in contact with them. Those who were responsible for cleaning up such substances were referred to as hazmat. (DIS: "Far From Home") Bio-mimetic gel was one example of a material that could become hazardous if not properly handled. (DS9: "Distant Voices")

Transporters were used to dispose of hazardous material as early as 2153. (ENT: "Chosen Realm")

In 2371, Doctor Julian Bashir requested that Ensign Vilix'pran be transferred from his cargo inspection duties, as he didn't want the pregnant crewman coming into contact with hazardous materials. (DS9: "Heart of Stone")

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