The term Holy Grail was used to denote a major, if not the major unsolved problem in a certain field of interest.

Upon learning about the Borg's desire for the Omega molecule in 2374, Kathryn Janeway called it the Borg's Holy Grail. (VOY: "The Omega Directive")

In 2375, Doctor Julian Bashir claimed that the Holy Grail of organ replacement would be to come up with a way to inject the patient with undifferentiated tissue that could become whatever organ is needed. (DS9: "When It Rains...")

The term comes from Christian mythology in which it was an artifact associated with Jesus Christ. The metaphorical meaning of the term was inspired by its role in Arthurian legend.

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