Hyperonic radiation is a type of radiation that is lethal to most humanoids. This type of radiation also renders transporters inoperable and randomizes phaser fire (although Data, a Soong-type android, adapted a phaser using one of his own servocircuits to be able to fire in such an environment).

Previous Federation research suggested that Humans could adapt to hyperonic radiation, perhaps through virotherapy. (TNG: "The Ensigns of Command")

The atmosphere of the planet Tau Cygna V had an abundance of hyperonic radiation that killed one-third of the crew of the SS Artemis after they were forced to land on the planet in 2274. The survivors adapted to the radiation and thrived to build a colony of over 15,000, though exactly how they adapted was not stated. (TNG: "The Ensigns of Command")

In 2369, Doctor Julian Bashir bombarded a sample of the aphasia virus, grown on tetracitrus gel, with hyperonic radiation at 430 millirads. (DS9: "Babel")

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