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Hypochondria was a psychological condition in which a person experienced abnormal and chronic anxiety over imagined illnesses.

Reginald Barclay suffered from hypochondria, as did William Telfer. It could be treated with medicine or counseling. Telfer, however, was afraid of both, which left The Doctor with simply scanning him and offering him reassurance. Following Telfer's experience with a possible dark matter lifeform, however, he seemed to be cured. (TNG: "Realm of Fear", "Genesis"; VOY: "Good Shepherd")

In 1996, when Tuvok refused to remove his shirt and experience 20th century weather, Tom Paris commented, "Vulcans. Deep down you're all a bunch of hypochondriacs." (VOY: "Future's End")

In Photons Be Free, the holonovel written by the USS Voyager's EMH, the Trill character based on Harry Kim, Kymble, was a hypochondriac. (VOY: "Author, Author")

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