Hypothermia was a medical condition in which the internal temperature of a living organism dropped below that which was required for normal metabolism and bodily function.

In 2151, Doctor Phlox treated a Klingon named Bu'kaH who was suffering from the effects of hypothermia. (ENT: "Sleeping Dogs")

That same year, Commander Charles Tucker III and Lieutenant Malcolm Reed of Enterprise NX-01 suffered hypothermia during a mission aboard the Enterprise's Shuttlepod 1 when the shuttle became low on oxygen and power. (ENT: "Shuttlepod One")

In 2266, a USS Enterprise landing party led by Hikaru Sulu suffered hypothermia and frostbite on the planet Alfa 177 when they were stranded on the planet's surface during the night as temperatures fell to 75 degrees below zero. (TOS: "The Enemy Within")

In 2373, Quark and Deep Space 9 security chief Odo suffered hypothermia during their ordeal on an unnamed planet after their runabout crash-landed there. (DS9: "The Ascent")

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