An interphasic signature was a high-frequency energy phenomenon emitted by a series of organisms which infested the USS Enterprise in 2370.

This signature was detected by Lieutenant Commander Data's positronic subprocessor, revealing the organisms' existence to the crew. Chief Engineer Geordi La Forge was then able to modify Data's subprocessor to emit a high-frequency interphasic pulse to eliminate the organisms. (TNG: "Phantasms")

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