In 3069, this class saw the loss of at least three of its ships to The Burn. Ships with active warp cores were destroyed when their dilithium became inert, resulting in antimatter explosions. (DIS: "People of Earth")
In 3189, the fleet at Federation Headquarters included the USS Voyager-J, a ship of this class. The collective energy of this fleet sustained a distortion field that concealed the headquarters' location. (DIS: "Die Trying")
- USS Voyager (NCC-74656-J)
In Star Trek Online, this class of ship is called the Janeway-class.