John Burke was a Human scientist, the chief astronomer at the Royal Academy in Old Britain during the mid-21st century.

He was responsible for mapping the area of space that included Sherman's Planet in 2067. (TOS: "The Trouble with Tribbles"; ENT: "In a Mirror, Darkly, Part II")

During a 2268 mission briefing for this incident, Ensign Chekov mistakenly remembered Burke as being a Russian named "Ivan Burkoff." (TOS: "The Trouble with Tribbles")

According to Star Trek: Star Charts (p. 33), John Burke named the system in which the planet Betazed was located Beta Zeta.
The audio commentary for "Terra Prime" suggests the comet Burke was named for Burke.
The Pocket Books novel Federation revealed that he had a daughter named Monica, while the Pocket TOS novel Prime Directive named one of USS Enterprise's shuttles after him.

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