The Kaleb sector was a sector known for being largely deserted. The closest Starfleet facility, on Draken IV, was two days away at maximum warp in Federation space.

In 2369, the Kaleb sector was where the IRW Khazara was to transfer some cargo containers to a Corvallen freighter in 2369, which would then rendezvous with the USS Enterprise-D a short time later to take the cargo to Starfleet Headquarters. The cargo contained Vice-Proconsul M'ret and his aides in stasis, members of the Romulan underground movement, who were defecting to the Federation. (TNG: "Face of the Enemy")

According to Star Trek: Star Charts (p. 66), this sector, located in the Beta Quadrant, was home for a network of Federation outposts code named Sierra, which were used for monitoring the Romulan Neutral Zone. This sector derived its name from the binary star system Kaleb. This system was also known as Caleb and Chi Eridani.

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