Karemma was an inhabited planet located in the Karemma system in the Gamma Quadrant. It was the homeworld of the Karemma, an important member of the Dominion. (DS9: "Rules of Acquisition")

In an effort to locate the Founders of the Dominion, the USS Defiant visited Karemma in 2371. (DS9: "The Search, Part I")

Minister Hanok, who worked for the Karemma Commerce Ministry, once saw a design schematic of a Jem'Hadar torpedo in the Ministry of Trade on Karemma.

After the USS Defiant rescued the crew of a Karemma starship in 2372, they were brought to Deep Space 9 until transport could be arranged back to Karemma. (DS9: "Starship Down")

According to Star Trek: Star Charts (p. 71), Karemma was a M-class planet. The official name of the planetary government was the Karemma Foundation. This government was seated in the capital city of Kecemen. Dominant species on this planet was the humanoid Karemman. In 2378, there were an estimated 4.5 billion Karemmans living on Karemma. This planet became warp-capable circa 2300. In 2372, trade relations were established between the Ferengi Alliance and the Karemma Foundation.

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