The Karemma system was a planetary system in the Gamma Quadrant. A planet in this system, Karemma, was the homeworld of the Karemma. This system was in Dominion space.
In 2371, upon entering into the Gamma Quadrant, T'Rul was ordered by Benjamin Sisko to set a course for this system in the USS Defiant. (TNG: "The Search, Part I")