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Kathleen Wirt played a female aphasia victim in the Star Trek: Deep Space Nine first season episode "Babel".

Wirt made her first acting appearance in Foxfire Light (1982). In her first television appearance, she played a Gucci saleslady on Miss Piggy's Hollywood. She then guest starred on A Different World (1992, starring Bumper Robinson and Jenifer Lewis, with Kenneth Mars and Vince Howard). Wirt appeared in Citizen Toxie: The Toxic Avenger IV (2000). She co-starred with another Deep Space Nine alum, Richard Ryder, in the Playboy 360 short film Love In Focus. Wirt and Ryder reprised their characters for Playboy two years later, playing the same bickering married couple in Honeymoon Suite.

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