The Khitomer system was an inhabited planetary system in the territory of the Klingon Empire, in the Beta Quadrant. This system contained the planet Khitomer, which was, by the mid-23rd century, the location of Camp Khitomer and a Klingon colony that, in turn, fell victim to a Romulan attack in 2346. (TNG: "Sins of The Father", display graphic)
In 2256, this system's location was labeled on the star chart "Alpha/Beta Quadrant Overview" in the ready room aboard the USS Discovery. The system was located in the territory of the Klingon Empire. (DIS: "Magic to Make the Sanest Man Go Mad", "The War Without, The War Within")
A year later, its location was labeled on the star chart showing the trajectory of Lieutenant Spock's shuttle. (DIS: "An Obol for Charon")
In 2258, the system's location was labeled on a star chart seen on the main viewscreen of the USS Enterprise. (DIS: "Such Sweet Sorrow, Part 2")
In 2259, the location of this system was labeled on a stellar cartography chart that was seen on the USS Enterprise's ready room viewscreen. This system's symbol was a red Klingon Empire logo, indicating its affiliation with the empire. (SNW: "Strange New Worlds", "Spock Amok")
In 2369, the location of Khitomer was labeled on the "Deep Space 9 Traffic Comm Database" star chart, where it was located within the territorial confines of the Romulan Star Empire. (TNG: "Birthright, Part II" display graphic)
The system's location was labeled in a Federation star chart that was in Fleet Admiral Kirsten Clancy's office at Starfleet Headquarters in 2399 and on the bridge of the USS Titan-A in 2401. The Khitomer system was in or near to Klingon space. (PIC: "Maps and Legends", "The Next Generation", "Disengage")
In the late 32nd century, this system was located in the Klingon Zone. (DIS: "There Is A Tide...")