Lady Macbeth was a character in William Shakespeare's play Macbeth. She was married to Macbeth, a general in King Duncan's army. In the play, Lady Macbeth was commonly seen as a malign influence on Macbeth, and was a by-word for an ambitious wife. She was seen as encouraging the murder of Duncan by Macbeth.

In 2266, Lenore Karidian performed the role of Lady Macbeth on Planet Q. That night, at a cocktail party, Captain James T. Kirk made a request of Lenore. He wanted to meet with Anton Karidian, the star and director of the Karidian Company of Players, and was informed by his daughter that he never met his fans personally and that he never attended parties. In response to this, Kirk said that he would talk with Lady Macbeth. (TOS: "The Conscience of the King")

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