A laser core sampler was a handheld laser drill and containment tool used by Starfleet.
In 2257, to gather a sample of the metreon particles embedded in a dark matter asteroid, Ensign Sylvia Tilly used a laser core sampler in conjunction with personal shielding. After successfully extracting a sample, an energy discharge of unknown origin knocked Tilly unconscious. (DIS: "New Eden")
Commander Paul Stamets later used the core sampler, with the asteroid sample inside, to draw a multidimensional fungal parasite out of Tilly's body. (DIS: "Point of Light")